MySims Agents for Nintendo DS is an adventure-puzzle game where players take on the role of a detective solving various mysteries throughout the Sims universe. Amidst a charming, cartoonish aesthetic, gamers engage in different cases by collecting clues, interrogating witnesses, and employing gadgets to uncover secrets. The gameplay involves completing puzzles to advance, with the help of quirky Sims characters, each with their own unique personalities. As agents build their reputation, they take on increasingly challenging missions to ultimately thwart the plans of an evil villain.