Destroy All Humans! is a whimsical action-adventure game with strong elements of satire and black humor. Set in the 1950s, players assume the role of Crypto, an alien tasked with infiltrating and subjugating humanity. As a third-person shooter with open-world exploration, gameplay involves using extraterrestrial weaponry and psychic abilities to battle humans, destroy towns, and collect DNA. Packed with pop culture references and parodies, the game's genre blends science fiction, stealth, and destruction within an interactive dark comedy experience.